The Janus-Faced Role of Antioxidants in Cancer Cachexia: New Insights on the Established Concepts

Table 1

Impact of allopurinol on cachexia symptoms in C26 mice. Balb/C mice subcutaneously inoculated with 1 × 10⁶ C26 cells have received daily dose of allopurinol (50 mg/kg/day) or vehicle (PBS). Mice weight was daily monitored and skeletal muscles were weighted at the end of the protocol. Fiber diameter was determined from at least 100–150 fibers per muscle histological section, stained with the Gomori method. Data are mean ± SEM (/group).

	Control	C26	C26-allo
Initial body weight (g)	23.6 ± 0.6	23.4 ± 0.6	23.9 ± 0.7
Final body weight (g)	25.9 ± 0.5	21.5 ± 2.1	20.1 ± 1.8
ΔBody weight (g)	2.3 ± 0.5	−2.2 ± 2.05	−3.8 ± 1.3
Soleus weight (mg)	7.1 ± 1.7	6.4 ± 2.3	7 ± 3.3
Gas weight (mg)	128.1 ± 14.4	94.5 ± 15.1	91.5 ± 22.7
EDL weight (mg)	10.7 ± 2.3	8 ± 1.8	8.2 ± 1.5
EDL fiber diameter (μm)	41.62 ± 2.4	29.8 ± 5.7	36.8 ± 5.2

versus control; versus C26; Gas: Gastrocnemius; and EDL: extensor digitorum longus.