Antipsychotic Treatment Reduces Indices of Oxidative Stress in First-Episode Psychosis Patients

Table 4

Regression coefficients () and significance values of log₁₀-transformed oxidative stress (OxS) markers’ levels in first-episode patients’ group after 7 months of treatment with antipsychotics compared to control subjects.

Biomarkers		(95% CI)	t-value	p value
OxS markers
TAC	0.02	−0.22–0.26	0.17	0.87
TPX	−0.01	−0.24–0.21		0.90
OSI	−0.02	−0.24–0.20		0.85
Met	0.24	0.02–0.47	2.21	0.03
Met-SO	−0.32	−0.54–(−0.09)		0.007
Met-SO/Met	−0.31	−0.53–(−0.10)		0.006

CI: confidence intervals; TAC: total antioxidant capacity; TPX: total level of peroxides; OSI: oxidative stress index; Met: methionine; Met-SO: methionine sulfoxide; Met-SO/Met: ratio of oxidized methionine to methionine.