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Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 9648769, 9 pages
http://dx.doi.org/10.1155/2016/9648769
Research Article

Nr2e1 Deficiency Augments Palmitate-Induced Oxidative Stress in Beta Cells

Department of Endocrinology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China

Received 13 April 2015; Revised 12 July 2015; Accepted 15 July 2015

Academic Editor: Ada Popolo

Copyright © 2016 Xiaoli Shi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. C. Weir and S. Bonner-Weir, “Islet β cell mass in diabetes and how it relates to function, birth, and death,” Annals of the New York Academy of Sciences, vol. 1281, no. 1, pp. 92–105, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. V. Poitout and R. P. Robertson, “Minireview: secondary β-cell failure in type 2 diabetes-a convergence of glucotoxicity and lipotoxicity,” Endocrinology, vol. 143, no. 2, pp. 339–342, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. J. L. Leahy, “Pathogenesis of type 2 diabetes mellitus,” Archives of Medical Research, vol. 36, no. 3, pp. 197–209, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. G. M. Steil, N. Trivedi, J.-C. Jonas et al., “Adaptation of beta-cell mass to substrate oversupply: enhanced function with normal gene expression,” The American Journal of Physiology—Endocrinology and Metabolism, vol. 280, no. 5, pp. E788–E796, 2001. View at Google Scholar · View at Scopus
  5. T. L. Jetton, J. Lausier, K. LaRock et al., “Mechanisms of compensatory β-cell growth in insulin-resistant rats: roles of Akt kinase,” Diabetes, vol. 54, no. 8, pp. 2294–2304, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. Y. Q. Liu, T. L. Jetton, and J. L. Leahy, “β-cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic zucker fatty rats,” The Journal of Biological Chemistry, vol. 277, no. 42, pp. 39163–39168, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. R. T. Yu, M. McKeown, R. M. Evans, and K. Umesono, “Relationship between Drosophila gap gene tailless and a vertebrate nuclear receptor Tlx,” Nature, vol. 370, no. 6488, pp. 375–379, 1994. View at Publisher · View at Google Scholar · View at Scopus
  8. A. P. Monaghan, D. Bock, P. Gass et al., “Defective limbic system in mice lacking the tailless gene,” Nature, vol. 390, no. 6659, pp. 515–517, 1997. View at Publisher · View at Google Scholar · View at Scopus
  9. K. A. Young, M. L. Berry, C. L. Mahaffey et al., “Fierce: A new mouse deletion of Nr2e1; violent behaviour and ocular abnormalities are background-dependent,” Behavioural Brain Research, vol. 132, no. 2, pp. 145–158, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. Y. Shi, D. C. Lie, P. Taupin et al., “Expression and function of orphan nuclear receptor TLX in adult neural stem cells,” Nature, vol. 427, no. 6969, pp. 78–83, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. C.-L. Zhang, Y. Zou, R. T. Yu, F. H. Gage, and R. M. Evans, “Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1,” Genes and Development, vol. 20, no. 10, pp. 1308–1320, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. Q. Qu, G. Sun, W. Li et al., “Orphan nuclear receptor TLX activates Wnt/β-catenin signalling to stimulate neural stem cell proliferation and self-renewal,” Nature Cell Biology, vol. 12, no. 1, pp. 31–40, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Sehgal, N. Sheibani, S. J. Rhodes, and T. L. Belecky Adams, “BMP7 and SHH regulate Pax2 in mouse retinal astrocytes by relieving TLX repression,” Developmental Biology, vol. 332, no. 2, pp. 429–443, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. G. Sun, K. Alzayady, R. Stewart et al., “Histone demethylase LSD1 regulates neural stem cell proliferation,” Molecular and Cellular Biology, vol. 30, no. 8, pp. 1997–2005, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. G. Sun, R. T. Yu, R. M. Evans, and Y. Shi, “Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 39, pp. 15282–15287, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. D. Wu, S. Yu, L. Jia et al., “Orphan nuclear receptor TLX functions as a potent suppressor of oncogene-induced senescence in prostate cancer via its transcriptional co-regulation of the CDKN1A (p21WAF1/CIP1) and SIRT1 genes,” Journal of Pathology, vol. 236, no. 1, pp. 103–115, 2015. View at Publisher · View at Google Scholar · View at Scopus
  17. H. Ishihara, T. Asano, K. Tsukuda et al., “Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets,” Diabetologia, vol. 36, no. 11, pp. 1139–1145, 1993. View at Publisher · View at Google Scholar · View at Scopus
  18. J.-I. Miyazaki, K. Araki, E. Yamato et al., “Establishment of a pancreatic β cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms,” Endocrinology, vol. 127, no. 1, pp. 126–132, 1990. View at Publisher · View at Google Scholar · View at Scopus
  19. E. Pepin, A. Higa, C. Schuster-Klein et al., “Deletion of apoptosis signal-regulating kinase1 (ASK1) protects pancreatic beta-cells from stress-induced death but not from glucose homeostasis alterations under pro-inflammatory conditions,” PLoS ONE, vol. 9, no. 11, Article ID e112714, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. R. B. Sharma and L. C. Alonso, “Lipotoxicity in the pancreatic beta cell: not just survival and function, but proliferation as well?” Current Diabetes Reports, vol. 14, no. 6, article 492, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Uemura, S. Kusuhara, S. J. Wiegand, R. T. Yu, and S.-I. Nishikawa, “Tlx acts as a proangiogenic switch by regulating extracellular assembly of fibronectin matrices in retinal astrocytes,” The Journal of Clinical Investigation, vol. 116, no. 2, pp. 369–377, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. W. Li, G. Sun, S. Yang, Q. Qu, K. Nakashima, and Y. Shi, “Nuclear receptor TLX regulates cell cycle progression in neural stem cells of the developing brain,” Molecular Endocrinology, vol. 22, no. 1, pp. 56–64, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. C.-L. Zhang, Y. Zou, W. He, F. H. Gage, and R. M. Evans, “A role for adult TLX-positive neural stem cells in learning and behaviour,” Nature, vol. 451, no. 7181, pp. 1004–1007, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. N. Ni, D. Zhang, Q. Xie et al., “Effects of let-7b and TLX on the proliferation and differentiation of retinal progenitor cells in vitro,” Scientific Reports, vol. 4, article 6671, 2014. View at Publisher · View at Google Scholar
  25. B. B. Lowell and G. I. Shulman, “Mitochondrial dysfunction and type 2 diabetes,” Science, vol. 307, no. 5708, pp. 384–387, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. K. Grankvist, S. L. Marklund, and I. B. Taljedal, “CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse,” Biochemical Journal, vol. 199, no. 2, pp. 393–398, 1981. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Tiedge, S. Lortz, R. Monday, and S. Lenzen, “Complementary action of antioxidant enzymes in the protection of bioengineered insulin-producing RINm5F cells against the toxicity of reactive oxygen species,” Diabetes, vol. 47, no. 10, pp. 1578–1585, 1998. View at Publisher · View at Google Scholar · View at Scopus
  28. H.-A. Seo and I.-K. Lee, “The role of Nrf2: adipocyte differentiation, obesity, and insulin resistance,” Oxidative Medicine and Cellular Longevity, vol. 2013, Article ID 184598, 7 pages, 2013. View at Publisher · View at Google Scholar
  29. B. N. Das, Y.-W. Kim, and Y.-S. Keum, “Mechanisms of Nrf2/keap1-dependent phase II cytoprotective and detoxifying gene expression and potential cellular targets of chemopreventive isothiocyanates,” Oxidative Medicine and Cellular Longevity, vol. 2013, Article ID 839409, 7 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus