Metformin Decreases Reactive Oxygen Species, Enhances Osteogenic Properties of Adipose-Derived Multipotent Mesenchymal Stem Cells <i>In Vitro</i>, and Increases Bone Density <i>In Vivo</i>

<div>Results of multipotency assay. Morphology of MuASCs cultured in standard (a), adipogenic (b), and osteogenic (c) conditions. Calcium deposits in mineralized extracellular matrix were visualized with Alizarin Red staining, while lipid droplets formed in adipogenic stimulation with Oil Red O. The images included in the figure were chosen to be representative. Magnification ×100, scale bar: 250 <i>μ</i>m.</div>

Oxidative Medicine and Cellular Longevity

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Figure 2: Metformin Decreases Reactive Oxygen Species, Enhances Osteogenic Properties of Adipose-Derived Multipotent Mesenchymal Stem Cells <i>In Vitro</i>, and Increases Bone Density <i>In Vivo</i> 

Figure 2 | Metformin Decreases Reactive Oxygen Species, Enhances Osteogenic Properties of Adipose-Derived Multipotent Mesenchymal Stem Cells In Vitro, and Increases Bone Density In Vivo 