Metformin Decreases Reactive Oxygen Species, Enhances Osteogenic Properties of Adipose-Derived Multipotent Mesenchymal Stem Cells In Vitro, and Increases Bone Density In Vivo

Figure 6

Assessment of oxidative stress and SOD activity in MuASC. To investigate whether treatment with metformin affects the oxidative status of MuASC, we investigated the extracellular levels of ROS (a) and NO (b). Moreover, the activity of antioxidant enzyme SOD was evaluated (c). Obtained data indicates that metformin supplementation decreases the oxidative stress and simultaneously improves the antioxidative protection coming from SOD. Results expressed as mean ± SD. value < 0.05, value < 0.001.

(a)

(b)

(c)