Periodic Exposure of Keratinocytes to Cold Physical Plasma: An In Vitro Model for Redox-Related Diseases of the Skin

Table 2

Expression (fold change compared to untreated control) of matrix-metalloproteinases and fibrous structural proteins (keratins) with at least one significant modulation throughout the time course of plasma treatment.

Gene name	Gene ID	w2	w6	w8	w10	w12
Matrilysin	MMP7	53.36	3.49	3.41	2.65	2.34
Matrix metallopeptidase 27	MMP27	3.00	4.16	3.81	2.74	3.16
Stromelysin 2	MMP10	2.08	124.31	2.81	2.10	2.27
Keratin I cytoskeletal 13	KRT13	−1.22	−5.77	−1.46	−1.35	−1.03
Keratin I cuticular Ha5	KRT35	1.43	12.00	1.71	1.61	1.20
Keratin I cuticular Ha8	KRT38	12.15	3.24	11.82	2.67	1.25
Keratin II cytoskeletal 1	KRT1	−1.21	−87.56	−2.72	−1.57	1.13
Keratin II cytoskeletal 1b	KRT77	−1.78	−41.78	−4.12	−2.51	−1.65
Keratin II cytoskeletal 4	KRT4	1.20	−3.27	−1.20	−1.15	−1.03
Keratin II cytoskeletal 8	KRT8	1.46	3.42	1.68	1.26	1.28
Keratin II cytoskeletal 72	KRT72	5.70	3.19	3.04	2.23	3.78
Keratin II cytoskeletal 79	KRT79	−1.08	−1.87	−1.63	6.24	−1.56
Keratin II cuticular Hb2	KRT82	1.35	2.86	2.74	1.94	3.03
Keratin II cuticular Hb3	KRT83	1.79	2.77	1.18	−1.24	1.28
Keratin-associated 3-3	KRTAP3-3	5.60	1.42	2.04	1.48	−1.01
Keratin-associated 4-1	KRTAP4-1	−1.18	−1.12	5.29	−1.11	1.21
Keratin-associated 4-2	KRTAP4-2	−1.10	−2.06	1.76	11.54	−2.28
Keratin-associated 10-7	KRTAP10-7	−1.76	3.76	2.81	3.08	3.84
Keratin-associated 10-10	KRTAP10-10	−1.11	−2.03	3.13	−1.62	−1.13
Keratin-associated 10-11	KRTAP10-11	5.66	3.17	−1.40	−1.42	1.72
Keratin-associated 10-12	KRTAP10-12	−1.27	8.01	4.78	2.68	1.25
Keratin-associated 13-3	KRTAP13-3	1.19	35.43	−1.23	−1.26	1.54
Keratin-associated 16-1	KRTAP16-1	−1.22	−1.30	−1.20	25.27	1.49
Keratin-associated 22-2	KRTAP22-2	−1.29	5.20	−1.54	−1.54	1.89
Filaggrin	FLG	−14.0	1.05	−1.23	−3.29	−1.41
Laminin subunit alpha-1	LAMA1	2.05	2.09	1.79	1.31	1.19
Late CE protein 1A	LCE1A	1.71	7.89	3.03	2.05	1.65
Loricrin	LOR	−1.68	−6.88	−2.35	−3.90	−1.18
Protein S100-A4	S100A4	−1.44	−4.27	−2.75	−1.14	−1.17
Protein S100-A6	S100A6	−1.06	−3.53	−1.65	−1.53	−1.25
Protein S100-A7	S100A7	1.23	−4.63	−4.54	1.28	1.51
Protein S100-A8	S100A8	1.02	−8.31	−3.31	1.21	1.17
Protein S100-12	S100A12	−1.39	−4.62	−2.42	1.28	1.28