Potential Modulation of Sirtuins by Oxidative Stress

Figure 2

Scheme of reactions catalyzed by sirtuins. Deacetylation is the most common reaction catalyzed by sirtuins, but some sirtuins catalyze deacylation of other posttranslational lysine modifications and mono ADP ribosylation. NAM = nicotinamide, OAADPR = O-acetyl-ADP-ribose.