Oxidative Medicine and Cellular Longevity / 2016 / Article / Fig 4

Research Article

Reduced HMGB 1-Mediated Pathway and Oxidative Stress in Resveratrol-Treated Diabetic Mice: A Possible Mechanism of Cardioprotection of Resveratrol in Diabetes Mellitus

Figure 4

Resveratrol attenuated myocardial fibrosis and inflammation in the hearts of experimental type 1 diabetic mice. (a) Representative Masson’s staining in four groups. (b) Quantitative analysis of CVF in four groups. (c) Representative western blot of TNF-α expression. (d) Representative western blot of iNOS level. Number of animals: 8 per group. versus N group; versus N group; versus DM group. Bar = 50 μm. CVF: collagen volume fraction; TNF-α: tumor necrosis factor-α; iNOS: inducible nitric oxide synthase; N: normal mice; DM: diabetic mice; DMR5: diabetic mice with 5 mg/kg/day resveratrol treatment; DMR25: diabetic mice with 25 mg/kg/day resveratrol treatment.
(a)
(b)
(c)
(d)

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at help@hindawi.com to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19. Sign up here as a reviewer to help fast-track new submissions.