Reduced HMGB 1-Mediated Pathway and Oxidative Stress in Resveratrol-Treated Diabetic Mice: A Possible Mechanism of Cardioprotection of Resveratrol in Diabetes Mellitus

Figure 4

Resveratrol attenuated myocardial fibrosis and inflammation in the hearts of experimental type 1 diabetic mice. (a) Representative Masson’s staining in four groups. (b) Quantitative analysis of CVF in four groups. (c) Representative western blot of TNF-α expression. (d) Representative western blot of iNOS level. Number of animals: 8 per group. versus N group; versus N group; versus DM group. Bar = 50 μm. CVF: collagen volume fraction; TNF-α: tumor necrosis factor-α; iNOS: inducible nitric oxide synthase; N: normal mice; DM: diabetic mice; DMR5: diabetic mice with 5 mg/kg/day resveratrol treatment; DMR25: diabetic mice with 25 mg/kg/day resveratrol treatment.

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