Activation of Antioxidative Functions by Radon Inhalation Enhances the Mitigation Effects of Pregabalin on Chronic Constriction Injury-Induced Neuropathic Pain in Mice

Figure 2

Changes in 50% paw withdrawal threshold following pregabalin (PGB) administration. (a) Changes in sham-operation (Sham-OP) or CCI surgery on 50% paw withdrawal threshold. versus pre-CCI (CCI), versus post-CCI (Sham-OP). (b) Time- and dose-dependent changes of 50% paw withdrawal threshold. , , and versus each CCI, , , and versus each sham-OP, and , versus each 1 mg. (c) Effectiveness comparison between radon and pregabalin. Values are presented as the mean ± SEM of data from 5-6 animals.

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