Mitochondrial Ferritin Deletion Exacerbates β-Amyloid-Induced Neurotoxicity in Mice

Figure 1

The effect of Ftmt ablation on A-induced spatial memory deficits. (a) Age-matched (10 months old) Ftmt knockout mice () and wild-type mice () were administered a 90 s trial four times a day to find the hidden platform. The analysis of the recorded data shows the changes in latency to find the hidden platform over the four consecutive days of training. (b) Ftmt knockout mice and wild-type mice were assessed in the probe test one day after the hidden platform test. The time spent in the target quadrant within the 90 s was recorded. (c) The effect of A on escape latency. (Wild-type mice and Ftmt knockout mice were randomly divided into four groups and injected with A or saline. Fifteen days later, the MWM test was conducted.) (d) The time spent in the target quadrant during the probe test after injecting A. The data is presented as the mean ± SD. versus WT + saline group, . , versus KO + saline group, . versus WT + A group, . KO + A, .

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