Mitochondrial Ferritin Deletion Exacerbates β-Amyloid-Induced Neurotoxicity in Mice

Figure 3

The effect of Ftmt deficiency on the Bcl-2/Bax ratio, cleaved caspase-3, and p38 MAPK activation in mice. Western blot and subsequent densitometric analysis of (a) the ratio of Bcl-2/Bax, (b) the amount of cleaved caspase-3, (c) the amount of cleaved PARP, and (d) the ratio of p-p38/p38. Data are presented as the mean ± SD, . , versus WT + saline group, , versus KO + saline group, and versus WT + A group. MAPK: mitogen-activated protein kinase.

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