Review Article

The Significance of Hypothiocyanite Production via the Pendrin/DUOX/Peroxidase Pathway in the Pathogenesis of Asthma

Table 1

Change of the machineries of the OSCN production system in asthma model mice and asthma patients.

MoleculeAsthma model mouseAsthma patient

Pendrin/→
CFTR
Heme peroxidase
 MyeloperoxidaseND
 Eosinophil peroxidaseND
 Lactoperoxidase/→
DUOX1
DUOX2/→

Expression changes of pendrin, CFTR, MPO, EPX, LPO, DUOX1, and DUOX2 in asthma model mice and asthma patients are depicted. ND: not detected. Referred from [9, 10].