Review Article

High Circulating Levels of ANGPTL2: Beyond a Clinical Marker of Systemic Inflammation

Table 2

Circulating levels of ANGPTL2 in cancer.

ReferencePatientsSerum ANGPTL2 (ng/ml)ELISA kitConclusion of the study

[30]Non-small-cell lung cancer, China8.4 ± 1.7 versus 4.9 ± 1.0 in controlsUSCN Life Science Inc., ChinaHigh ANGPTL2 is a novel potential biomarker for diagnosis and prognosis of patients with non-small-cell lung cancer.
[32]Breast cancer, Japan~4.0 versus 2.0 in controlsIBL, JapanHigh ANGPTL2 in breast cancer patients could represent a potential marker of breast cancer metastasis.
[33]Hepatocellular carcinoma, ChinaValues not given
(ANGPTL2 not increased in cancer patients)
Not mentionedANGPTL2 drives hepatocellular carcinoma metastasis.
[34]Esophageal cancer, Japan~1.5 versus 0.8 in controlsIBL, JapanHigh ANGPTL2 is a novel biomarker for diagnosis and prognosis of patients with esophageal cancer.
[40]Colorectal cancer, Japan~1.5 versus 0.8 in controlsIBL, JapanANGPTL2 is a potential marker for diagnosis, early recurrence and prognosis in colorectal cancer patients.
[38]Colorectal cancer, Japan1.9 (meta (+)) versus 1.5 (meta (−))IBL, JapanANGPTL2 improves preoperative detection of lymph node metastasis in colorectal cancer.
[39]Gastric cancer, Japan~1.5 versus 0.8 in controlsIBL, JapanHigh ANGPTL2 correlates with the metastatic properties of gastric cancer and could be a biomarker for early diagnosis and recurrence.
[41]Colorectal cancer, Japan~3.5 versus 2.7 in controlsIBL, JapanHigh ANGPTL2 could be a potential biomarker for early detection of colorectal cancer.
[42]Gastric cancer, Japan~3.6 versus 2.7 in controlsIBL, JapanHigh ANGPTL2 could be a potential biomarker for gastric cancer.