High Circulating Levels of ANGPTL2: Beyond a Clinical Marker of Systemic Inflammation

Table 3

Circulating levels of ANGPTL2 in autoimmune diseases.

Reference	Patients	Serum ANGPTL2 (ng/ml)	ELISA kit	Conclusion of the study
[61]	Dermatomyositis versus controls, Japan	~3.8 versus 3.0 in controls	IBL, Japan	Keratinocyte-derived ANGPTL2 contributes to DM pathogenesis by inducing chronic inflammation in skin tissue.
[62]	Rheumatoid arthritis versus controls, Japan	~3.0 versus 3.0 in controls (NS)	IBL, Japan	Synovial fluid-derived ANGPTL2 (not serum) acts as an important rheumatoid inflammatory mediator in RA pathogenesis.

DM: dermatomyositis; NS: nonsignificant; RA: rheumatoid arthritis.