Oxidative Stress-Related Parthanatos of Circulating Mononuclear Leukocytes in Heart Failure

Table 2

Pearson correlation of oxidative-nitrative stress markers, PARP activity, AIF translocation with ejection fraction, and pro-BNP levels.

		All subjects		CHF patients
		EF (%)	Log[pro-BNP (pg/mL)]	EF (%)	Log[pro-BNP (pg/mL)]
Total peroxide (μmol/L)	R	−0.458	0.531	−0.245	0.577
	p	0.028	0.009	0.444	0.049
	N	23	23	12	12
TAC (μmol CRE)	R	−0.244	0.142	0.226	−0.412
	p	0.165	0.424	0.351	0.08
	N	34	34	19	19
OSI (total peroxide/CRE)	R	−0.466	0.537	−0.339	0.630
	p	0.025	0.008	0.291	0.028
	N	23	23	12	12
Log[HNE area (%)]	R	−0.682	0.628	0.336	0.331
	p	0.00002	0.0001	0.187	0.195
	N	32	32	17	17
Log[NT area (%)]	R	−0.368	0.497	−0.213	0.051
	p	0.032	0.009	0.381	.836
	N	34	34	19	19
Log[PAR area (%)]	R	−0.466	0.576	−0.004	0.474
	p	0.006	0.000	0.986	0.047
	N	33	33	18	18
Log[AIF cell (%)]	R	−.431	.472	0.000	−.169
	p	0.035	0.020	0.999	0.620
	N	24	24	11	11

Statistical analysis: Pearson correlation was performed between continuous variables. In order to provide the normal distribution of variables that initially violated normality, logarithmic transformation was implemented. R: Pearson coefficient; p: significance; N: number of cases in each calculation. pro-BNP: N-terminal probrain-type natriuretic peptide; TAC: total antioxidant capacity; CRE: copper reducing equivalent; OSI: oxidative stress index; HNE: anti-4-hydroxynoneal; NT: nitrotyrosine; PAR: poly(ADP-ribose); AIF: apoptosis-inducing factor.