Small Dense Low-Density Lipoprotein as Biomarker for Atherosclerotic Diseases

Table 1

LDL subclasses separated by different laboratory methods.

			Small dense LDL
Method	LDL I; Large	LDL II; Intermediate	LDL III; Small	LDL IV; Very small
UC density gradient (density)
(a) [44]	(a) 1.019–1.023 g/ml	(a) 1.023–1.034 g/ml	(a) 1.034–1.044 g/ml	(a) 1.044–1.060
(b) [26]	(b) 1.025–1.034 g/ml	(b) 1.034–1.044 g/ml	(b) 1.044–1.060 g/ml
UC iodixanol gradient (density)
(a) [28]	(a) 1.016–1.028 g/ml		(a) 1.028–1.043 g/ml
(b) [29]	(b) 1.022–1.028 g/ml		(b) 1.028–1.041 g/ml
GGE (peak diameter)
(a) [30]	(a) 26.35–28.5 nm	(a) 25.75–26.34 nm	(a) 22.0–25.74 nm
(b) [45]	(b) 26.0–28.5 nm	(b) 25.5–26.4 nm	(b) 24.7–25.5 nm (III A); 24.2–24.6 nm (III B)	(b) 23.3–24.1 nm (IV A); 22.0–23.2 nm (IV B)
Ion mobility (peak size) [39]	21.9–23.8 nm	21.1–21.9 nm	20.17–21.1 nm	18.0–20.17 nm
NMR (peak size)
(a) [34, 35]	(a) 21.3–22.7 nm	(a) 19.8–21.2 nm	(a) 18.3–19.7 nm
(b) [32]	(b) 20.6–22.0 nm	(b) 20.4–20.5 nm	(b) 19.0–20.3 nm
Homogenous assay [42, 43]			Separated particles with density 1.044–1.063 g/ml
	Phenotype pattern A		Phenotype pattern B