Probucol Protects Rats from Cardiac Dysfunction Induced by Oxidative Stress following Cardiopulmonary Resuscitation

<div>(a) Western blot analysis using anti-KEAP1 reveals that KEAP1 protein expression is elevated in myocardial tissue of CA model rat heart (C) comparing to sham control rat heart (B ). The effect of probucol moderated the KEAP1 level induced by CA in a dose-dependent manner (D–F). Lane (A) shows KEAP1 by Western blotting with HeLa cell extract. KEAP1 protein is also analyzed in cytosolic (G) and nucleic (H) fractions of myocardial tissues of sham control to show the subcellular localization. (b). Relative density of the KEAP1 protein detected by Western blotting after normalizing with GAPDH. Data are expressed as mean ± SD with three measurements. 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Probucol Protects Rats from Cardiac Dysfunction Induced by Oxidative Stress following Cardiopulmonary Resuscitation 