Probucol Protects Rats from Cardiac Dysfunction Induced by Oxidative Stress following Cardiopulmonary Resuscitation

Table 2

Effect of probucol on myocardial MDA and antioxidant enzyme activities 12 hour after ROSC (; ).

Group	MDA (mmol/l)	CAT (U/l)	GPx (U/l)	GSH (U/l)	SOD (U/l)
Sham operated	3.18 ± 0.33	3.75 ± 0.82	26.06 ± 3.47	23.53 ± 2.54	1.94 ± 0.61
CA model	5.55 ± 1.07	1.82 ± 0.40	15.76 ± 3.02	13.65 ± 2.11	0.84 ± 0.34
CA + low dose	4.80 ± 0.76	1.99 ± 0.34	19.56 ± 2.64^†	17.43 ± 2.91^†	1.21 ± 0.42^†
CA + medium dose	3.43 ± 0.83^†§	2.54 ± 0.82^‡§	19.34 ± 2.79^‡	19.98 ± 3.02^†§	1.47 ± 0.60^‡
CA + high dose	3.29 ± 0.46^‡¶	3.21 ± 0.75^‡¶††	22.00 ± 2.35^‡§††	19.28 ± 1.45^‡§	1.71 ± 0.63^‡§

versus the sham-operated group; ^† and ^‡ versus the animal model group; ^§ and ^¶ versus the low-dose group; ^†† versus the medium-dose group. CAT: catalase; GPx: glutathione peroxidase; GSH: glutathione; MAD: malondialdehyde; ROSC: return of spontaneous circulation; SOD: superoxide dismutase.