Oxidative Medicine and Cellular Longevity

Research Article

Probucol Protects Rats from Cardiac Dysfunction Induced by Oxidative Stress following Cardiopulmonary Resuscitation

Table 3

Effect of probucol on hemodynamic parameters 12 hours after ROSC (; ).


Group	HR/min	MAP (mmHg)	+dP/dt_max	−dP/dt_max

Sham operated	420.31 ± 17.41	134.44 ± 4.91	6145.63 ± 348.09	4903.41 ± 278.45
CA model	336.63 ± 20.31	94.62 ± 7.64	3533.01 ± 135.81	2698.25 ± 199.32
CA + low dose	391.34 ± 18.76^‡	103.71 ± 4.92	3865.41 ± 219.76^†	2937.49 ± 301.76^†
CA + medium dose	394.20 ± 17.76^‡	105.29 ± 6.29	3904.03 ± 178.62^‡§	3231.01 ± 210.93^‡§
CA + high dose	408.54 ± 16.29^‡	114.94 ± 7.09^‡§††	4376.29 ± 185.73^‡¶‡‡	3813.13 ± 108.82^‡¶‡‡

versus the sham-operated group; ^† and ^‡ versus the animal model group; ^§ and ^¶ versus the low-dose group; ^†† and ^‡‡ versus the medium-dose group. +dP/dt_max: maximal rate of rise of left ventricular pressure; −dP/dt_max: maximal rate of fall of left ventricular pressure HR: heart rate; MAP: mean arterial pressure; ROSC: return of spontaneous circulation.