Oxidative Phosphorylation System in Gastric Carcinomas and Gastritis

Figure 5

Sequence analysis of complex I coding mtDNA genes in an intestinal GC (case M5). (a) Sequence analysis showing the normal sequence for the poly C stretch of the ND4 gene from normal corresponding tissue. (b) Sequence analysis showing an insertion of cytosine in the poly cytosine stretch of the ND4 gene in the tumor tissue. The mutation appears to be heteroplasmic, but the tissue of case M5 was heterogeneous and contaminated with nontumor cells. In addition, complex IV was reduced in M5 (Figures 1(h) and 1(k)).

(a)

(b)