Rat Liver Enzyme Release Depends on Blood Flow-Bearing Physical Forces Acting in Endothelium Glycocalyx rather than on Liver Damage

Figure 1

Effect of CHM administration on the pattern of serum enzyme activities at various times after 70% PH. Enzyme activities are expressed as mean ± SE for six independent determinations per experimental point for LDH, ALT, AST, GDH, and OCT, after 24 h after surgery. In panel (a), empty symbols represent 70%-PH rats, and solid symbols represent those PH animals in vivo treated with 1.8 mg/kg, b.w., of CHM, 6 h before euthanasia. Enzyme release in vitro from isolated livers from PH rats without (panel (b)) or with (panel (c)) in vivo treatment with CHM is also shown.

(a) Serum

(b) Nontreated

(c) Treated with CHM