Research Article
Mitochondrial Respiration in Human Colorectal and Breast Cancer Clinical Material Is Regulated Differently
Figure 2
(a) Oxygraphic analysis of the functioning of complex I in skinned tissues from patients with HBC or HCC; here, VGlut/VSucc is the ratio of ADP-stimulated respiration rate in the presence of 5 mM glutamate and 2 mM malate (activity of complex I) to ADP-stimulated respiration rate in the presence of 50 μM rotenone and 10 mM succinate (activity of complex II). (b) VSucc/VCOX is the ratio of complex II respiration rate to complex IV respiration rate. Data shown as mean ± SEM; for colon [28] and breast tissue samples [26], .
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