Mitochondrial Respiration in Human Colorectal and Breast Cancer Clinical Material Is Regulated Differently

Figure 8

Mitochondrial alterations in HCC and HBC tissue cells. Mitochondrial interactosome is a large supercomplex consisting of ATP synthasome, VDAC, mitochondrial kinases like adenylate kinase, hexokinase or mitochondrial creatine kinase (MtCK), and respiratory chain (super)complexes. Here, the octameric MtCK characteristic is shown for the striated muscles and also as the possible component of the MI in the healthy colon [108–110]. The complex of VDAC together with other proteins controls the exchange of adenine nucleotides and regulates energy fluxes between mitochondrial and cytosolic compartments. Changes in the structure and function of MI are the important parts of cancer mitochondrial metabolism.