Mitochondrial Respiration in Human Colorectal and Breast Cancer Clinical Material Is Regulated Differently

Table 2

FCCs for different components in mitochondrial Interactosome and ranges of the concentrations of inhibitors.

MI component	Inhibitor	Range of inhibitor concentration		FCC
			HCC	Control colon tissue (mucosa)	HBC
Complex I	Rotenone	1–100 nM	0.56	0.45	0.46
Complex II	Atpenin A5	0.1–6 μM	0.12	0.13	0.28
Complex III	Antimycin	1–200 nM	0.68	0.66	0.54
Complex IV	Na cyanide	0.1–40 μM	0.31	0.50	0.74
ANT	Carboxyatractyloside	1–200 nM	0.28	0.97	1.02
ATP synthase	Oligomycin	1–600 nM	0.25	0.24	0.61
Pi transporter	Mersalyl	1–200 μM	0.43	0.53	0.60
Sum 1, 3–7	Total (NADH)		2.08	2.82	3.36
Sum 2–7	Total (succinate)		2.07	3.03	3.78

Note: from [26].