Diallyl Trisulfide Suppresses Oxidative Stress-Induced Activation of Hepatic Stellate Cells through Production of Hydrogen Sulfide

Figure 1

DATS inhibits viability and reduces fibrotic protein expression associated with H₂S in HSCs. (a) LDH release assay. Significance: versus DMSO and versus DMSO. (b) MTT assay. Significance: ^# versus DMSO, versus DMSO + H₂O₂, and versus DMSO + H₂O₂. (c) Western blot analyses of profibrotic marker proteins. (d) Morphology evaluation with light microscope (200x magnification). (e) ELISA for H₂S concentration. Significance: versus DMSO, versus DMSO, and ^# versus DATS 10 μM. (f) Western blot analyses of profibrotic marker proteins.

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