Oxidative Medicine and Cellular Longevity / 2017 / Article / Fig 1

Review Article

Reactive Oxygen Species-Mediated Mechanisms of Action of Targeted Cancer Therapy

Figure 1

Expected ROS-mediated effects of targeted therapies. In addition to the respective signalling pathway that a targeted agent affects, the diagram represents their putative ROS-related effects. CRC: colorectal cancer; GISTs: gastrointestinal stromal tumours; RCC: renal cell carcinoma; ROS: reactive oxygen species; O2•−: superoxide; H2O2: hydrogen peroxide; NO: nitric oxide; ΔΨ: mitochondrial membrane polarity; TCA: tricarboxylic acid cycle; m: methylation; NFE2L2: nuclear factor erythroid 2-related factor 2.