Reactive Oxygen Species-Mediated Mechanisms of Action of Targeted Cancer Therapy

<div>Expected ROS-mediated effects of targeted therapies. In addition to the respective signalling pathway that a targeted agent affects, the diagram represents their putative ROS-related effects. CRC: colorectal cancer; GISTs: gastrointestinal stromal tumours; RCC: renal cell carcinoma; ROS: reactive oxygen species; O<sub>2</sub><sup>•−</sup>: superoxide; H<sub>2</sub>O<sub>2</sub>: hydrogen peroxide; NO<sup>•</sup>: nitric oxide; Δ<i>Ψ</i>: mitochondrial membrane polarity; TCA: tricarboxylic acid cycle; m: methylation; NFE2L2: nuclear factor erythroid 2-related factor 2.</div>

Oxidative Medicine and Cellular Longevity

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Figure 1

Figure 1: Reactive Oxygen Species-Mediated Mechanisms of Action of Targeted Cancer Therapy 