Oxidative Stress Alters the Profile of Transcription Factors Related to Early Development on In Vitro Produced Embryos

Table 3

Transcription factors with difference between the 5% O₂ and 20% O₂ groups separated by functional pathways.

Function	Transcription factors
DNA-dependent transcription factors (processes that regulate frequency, rate, and extent of DNA transcription)	ATF4  CDX2  DDIT3  KEAP1  HSF1
	OTX2  PAF1  POU5F1
	REST  SREBF1  XBP1
	HAND1  NANOG  NFKB2  SOD2  SOX2
Positive regulation of gene expression	ATF4  DDIT3  KEAP1  SREBF1
Negative regulation of gene expression	REST
	HAND1  NANOG  SOX2
DNA-dependent transcription factors with specific binding	DDIT3  ATF4  HSF1
	POU5F1  OTX2
	NANOG  NFKB2  SOX2
RNA metabolic process regulators (processes that regulate frequency, rate, and extent of chemical reactions involving RNA	ATF4  DDIT3  CDX2  HSF1
	POU5F1  OTX2  XBP1
	HAND1  NANOG  NFKB2  SOD2  SOX2

Genes in italic upregulated in the 5% O₂ group in comparison to the 20% O₂ group. Genes in bold downregulated in the 5% O₂ group in comparison to the 20% O₂ group.