Impact of Atherosclerosis- and Diabetes-Related Dicarbonyls on Vascular Endothelial Permeability: A Comparative Assessment

<div>Effects of dicarbonyls on FITC-dextran diffusion through the EA.hy926 endothelial cell monolayer. Cells were challenged with 250 <i>μ</i>M MDA, GO, or MGO, and the amount of FITC-dextran diffused through the monolayer was measured 15 hours after its addition on top of the monolayer; this value was normalized by a maximum value of permeability attained in a particular experiment; data from three independent experiments were pooled. <svg height="13.532pt" id="M12" style="vertical-align:-3.4295pt" version="1.1" viewbox="-0.0498162 -10.1025 50.6052 13.532" width="50.6052pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 225 288 275 262C225 236 198 227 145 220C133 201 125 177 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Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: Impact of Atherosclerosis- and Diabetes-Related Dicarbonyls on Vascular Endothelial Permeability: A Comparative Assessment 