The Hepatoprotective and MicroRNAs Downregulatory Effects of Crocin Following Hepatic Ischemia-Reperfusion Injury in Rats

Figure 1

Representative microscopic images (magnification ×300) of H&E stained liver sections following hepatic IR injury. (a) Sham group shows normal appearance and there were not any histopathological changes in liver tissue; (b) IR group shows many histopathological changes including structural disarrangement of liver parenchyma, vascular congestion, central vein dilation (CV), and necrotic cells; (c) Cr group shows normal architecture; and (d) Cr + IR group, except mild dilated sinusoids, restored histopathological changes to approximately normal compared to IR group.

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