The Hepatoprotective and MicroRNAs Downregulatory Effects of Crocin Following Hepatic Ischemia-Reperfusion Injury in Rats

Figure 2

Immunohistochemical staining of liver Nrf2 expression (immunohistochemistry, ×300). Sham group: Nrf2 localized predominantly in cytoplasm of hepatocytes. IR group: Nrf2 expression decreased in cytoplasm and moderately increased in nucleus. Cr group: The immune reaction was moderate in cytoplasm. Cr + IR group: Nrf2 expression increased both in nucleus and in cytoplasm, but its expression was in nucleus higher than in cytoplasm.