The Hepatoprotective and MicroRNAs Downregulatory Effects of Crocin Following Hepatic Ischemia-Reperfusion Injury in Rats

Figure 4

The effects of crocin pretreatment on antioxidant activity of GPx (a), CAT (b), and SOD (c) following hepatic IR injury. The levels of antioxidant activity of GPX, CAT, and SOD in IR rats were significantly lower than in sham group. Pretreatment with crocin restored these levels to normal. Results are expressed as mean ± SEM. and significant difference versus the IR group. GPx: glutathione peroxidase; SOD: superoxide dismutase; CAT: catalase. Cr: crocin pretreatment; IR: ischemia/reperfusion; S: sham; Cr + IR: animals received crocin at 200 mg/Kg (ip) for seven consecutive days prior to induction of IR; U/L: unit per liter. .

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