The Hepatoprotective and MicroRNAs Downregulatory Effects of Crocin Following Hepatic Ischemia-Reperfusion Injury in Rats

Figure 5

Effects of crocin pretreatment on serum levels of AST (a) and ALT (b) following hepatic IR injury. The results showed that the crocin pretreatment (200 mg/Kg, ip, seven consecutive days) decreased the serum levels of AST and ALT in comparison with IR group. Results are expressed as mean ± SEM. , , and significant difference versus the IR group. AST: aspartate aminotransferase and ALT: alanine aminotransferase. Cr: crocin pretreatment; IR: ischemia/reperfusion; S: sham; Cr +IR: animals received crocin at 200 mg/Kg (ip) for seven consecutive days prior to induction of IR; U/L: unit per liter.

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