The Hepatoprotective and MicroRNAs Downregulatory Effects of Crocin Following Hepatic Ischemia-Reperfusion Injury in Rats

<div>Effects of crocin pretreatment on protein expression of p53 following hepatic IR injury. Analysis of western blot results showed that the level of protein expression of p53 in IR group was significantly higher than in sham, Cr, and Cr + IR groups. Crocin pretreatment significantly decreased this level to near normal. 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horiz-adv-x="480" vert-adv-y="480"></glyph.data></g></svg> versus the IR group. Cr: crocin pretreatment; IR: ischemia/reperfusion; S: sham; Cr + IR: animals received crocin at 200 mg/Kg (ip) for seven consecutive days prior to induction of IR.</div>

Oxidative Medicine and Cellular Longevity

fig7

Figure 7

Figure 7: The Hepatoprotective and MicroRNAs Downregulatory Effects of Crocin Following Hepatic Ischemia-Reperfusion Injury in Rats 