Brain-Derived Neurotrophic Factor Attenuates Septic Myocardial Dysfunction via eNOS/NO Pathway in Rats

Figure 1

BDNF expressed in cardiomyocytes was reduced after septic shock, and supplementation of BDNF improved survival rate in rats subjected to septic shock. (a) Schematic diagram of the protocol. (b) BDNF protein expression in isolated cardiomyocytes. (c) BDNF protein expression in heart tissues. (d) Survival rates in rats subjected to septic shock. Data are mean ± SEM, with animals per group. versus sham; ^# versus CLP; . CLP: cecal ligation and puncture; rhBDNF: recombined BDNF protein.

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