Brain-Derived Neurotrophic Factor Attenuates Septic Myocardial Dysfunction via eNOS/NO Pathway in Rats

Figure 2

BDNF reduced cardiac hypertrophy in septic shock rats that was attenuated by L-NAME. (a and b) Myocardial fibrosis content assessed by Masson’s trichrome staining (400x magnification) and quantitation. (c) The cell size visualization by H&E staining (400x magnification). Data are mean ± SEM, with animals per group. versus sham; ^# versus CLP; ^& versus CLP + rhBDNF. CLP: cecal ligation and puncture; rhBDNF: recombined BDNF protein.

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