Oxidative Medicine and Cellular Longevity

Research Article

Brain-Derived Neurotrophic Factor Attenuates Septic Myocardial Dysfunction via eNOS/NO Pathway in Rats

Table 1

BDNF improved cardiac function in septic shock rats that was reduced by L-NAME.


Group	HR (beats/min)	MABP (mmHg)	LV dP/dt_max (mmHg/s)	LV dP/dt_min (mmHg/s)	LVEDP (mmHg)	LVSP (mmHg)

Sham	430 ± 52	110.52 ± 12.64	6682 ± 646	−4818 ± 356	11.22 ± 4.86	130.24 ± 11.46
CLP	460 ± 42	68.46 ± 15.38	3980 ± 386	−2860 ± 246	19.82 ± 5.02	89.74 ± 9.12
CLP + BDNF	446 ± 54	96.86 ± 12.12^#	6024 ± 562^#	−4328 ± 302^#	13.02 ± 4.06^#	124.68 ± 12.48^#
CLP + BDNF + L-NAME	458 ± 50	70.02 ± 10.46^&	4126 ± 428^&	−3022 ± 286^&	18.98 ± 5.82^&	94.56 ± 10.06^&

HR: heart rate; MABP: mean arterial blood pressure; LV dP/dt_max: left ventricular (LV) maximal pressure development; LV dP/dt_min: left ventricular (LV) minimal pressure development; LVEDP: left ventricular end-diastolic pressure; LVSP: left ventricular systolic pressure. Data are mean ± SEM. versus control group, ^# versus CLP group, ^& versus CLP + rhBDNF. CLP: cecal ligation and puncture; rhBDNF: recombined BDNF protein.