Regulation of Sirtuin-Mediated Protein Deacetylation by Cardioprotective Phytochemicals

Figure 1

(a) NAD⁺-dependent deacetylation reaction performed by sirtuins. NAD⁺ is synthesized from its precursor NMN and degraded into NAM + acetyl-ADP-ribose once sirtuins utilize it for their activation [10–12]. Activated sirtuins interact with their target protein and transfer the acetyl group from target lysine residues to ADP-ribose. (b) Sirtuins1–7, their subcellular localization, and the enzymatic activity they perform; yellow stars indicate deacetylase activity [13, 14, 17, 18]. NAD: nicotinamide dinucleotide; NMN: nicotinamide mononucleotide; Nmnat: nicotinamide mononucleotide adenylyltransferase; Nampt: nicotinamide phosphoribosyltransferase.

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