Regulation of Sirtuin-Mediated Protein Deacetylation by Cardioprotective Phytochemicals

Figure 4

Cardioprotective effects of sirtuin activators and the molecular pathways involved. Red boxes state the phytochemicals regulating the activity of Sirt1, Sirt3, or both, as indicated by the green connecting lines. Green lines indicate activation of the indicated targets, whereas red lines indicate inhibition. Gray boxes indicate inhibition of cellular responses and white boxes indicate stimulation of them. CAE: caffeic acid ethanolamide; a-LA: alpha-lipoic acid; DHA docosahexaenoic acid.