Diabetes-Related Induction of the Heme Oxygenase System and Enhanced Colocalization of Heme Oxygenase 1 and 2 with Neuronal Nitric Oxide Synthase in Myenteric Neurons of Different Intestinal Segments

Figure 1

The serum level of HO1 and HO2 in acute (a, c) and chronic (b, d) diabetic rats. The HO1 expression increased significantly in the 3-day diabetics with a recovery in the 5-day-diabetic rats, and it decreased further in the 10-day-diabetic animals as compared to the controls (a). The serum HO1 level was almost the same in the 10-week and the 10-day diabetics (a, b). The serum concentration of HO2 was also decreased in 5-day-, 10-day-, and 10-week-diabetic animals as compared to their controls (c, d). Data are expressed as means ± SEM. (compared to the controls), ; ; (compared to the 3-day diabetics). C: controls; 3dD: 3-day diabetics; 5dD: 5-day diabetics; 10dD: 10-day diabetics; D: 10-week diabetics.

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