Comparative Therapeutic Effects of Minocycline Treatment and Bone Marrow Mononuclear Cell Transplantation following Striatal Stroke

Figure 2

Inhibition of microglial activation by minocycline and BMMCs after striatal ischemia. Animals treated with saline (a, b), BMMCs (c, d), or minocycline (e, f) 7 days after ischemic induction. Quantification of ED1+ cells in all experimental groups (g). Minocycline treatment and BMMC transplantation reduced the number of ED1+ cells, with better results for BMMCs ().Comparison of saline versus minocycline. ⁺Comparison of saline versus BMMCs. ^#Comparison of BMMCs versus minocycline. Arrows point to ED1+ cells. demarcates lesion center (a–f). Scale bars: 400 μm (a, c, e); 40 μm (b, d, f).

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