Increased Circulating Levels of Interleukin-6 Induce Perturbation in Redox-Regulated Signaling Cascades in Muscle of Dystrophic Mice

<div>IL-6 exacerbates the oxidant-related damage in the dystrophic muscle. Increased levels of IL-6 could contribute to amplify degenerative processes in mdx mice by enhancing the expression of both gp91phox and NF<i>κ</i>B and by reducing the Nrf2-antioxidant response.</div>

Oxidative Medicine and Cellular Longevity

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Figure 5

Figure 5: Increased Circulating Levels of Interleukin-6 Induce Perturbation in Redox-Regulated Signaling Cascades in Muscle of Dystrophic Mice 