|
| Reference | Tissue | Subject | Comparative | Results |
|
| [58] | Muscle | Humans | Sedentary and active youths and elderly | NS (mRNA): PGC-1α; TFAM; Fis1; Mfn1 |
| [45] | Carotid arteries | Mouse | Sedentary and active youths and elderly | ↓: PGC-1α; Mfn2 |
| ↑: Fis1 |
| [46] | Muscle | Humans | Youths/elderly | ↓: PGC-1α; OPA1 |
| NS: Mfn2; Drp1; Fis1 |
| [47] | Muscle | Rats | Youths/elderly | ↓ (mRNA and protein): PGC-1α; TFAM |
| [73] | Muscle | Mouse | Youths/elderly | ↑: Nix; LC3 |
| [48] | Muscle | Rats | Youths/elderly | ↓: PGC-1α |
| ↑: TFAM; Fis1; Mfn1 |
| [30] | Muscle | Humans | Youths/elderly | NS: PGC-1α; Mfn1; Mfn2; Fis1 |
| [49] | Muscle | Humans | Youths/elderly | NS: PGC-1α; TFAM |
| [68] | Muscle | Humans | Youths/elderly | NS (mRNA): PGC-1α; TFAM; beclin1; Bnip3 |
| NS: Parkin; PINK1; VDAC1 |
| [50] | Muscle | Humans | Youths and active and sedentary elderly | ↓: PGC-1α |
| [72] | Muscle | Humans | Youths and active and sedentary elderly | ↑: PGC-1α; beclin1 (elderly versus youths); Bnip3 (sedentary elderly versus youths) |
| NS: Bnip3 (active elderly versus youths) |
| [71] | Muscle | Humans | Youths/elderly | NS: VDAC1 |
| [43] | Muscle | Mouse | Youths/elderly | ↓: beclin1; Fis1 |
| ↑: Mfn1; Mfn2 |
| NS: PGC-1α; TFAM; OPA1; Drp1; LC3II |
| [67] | Heart | Rats | Youths, old adult, and senescent | ↓: Bnip3; Drp1; Fis1 |
| ↑: OPA1 (old adults versus youths); Mfn2; LC3I |
| NS: beclin1; LC3II |
| [59] | Gastrocnemius (G) and triceps (T) muscle | Rats | Youths/elderly | ↓ (G): Drp1; Fis1; beclin1; LC3II; (T): PINK1; VDAC1 |
| ↑ (G): OPA1; Mfn1; VDAC1; (T): OPA1; Mfn1; Drp1; Fis1 |
| NS: (G): PINK1; (T) beclin1; LC3II |
| [51] | Muscle | Rats | Youths/elderly | ↓: PGC-1α |
| ↑: TFAM |
| [55] | Cerebellum, heart, kidney, and liver | Rats | Youths/elderly | ↑: TFAM |
| NS (heart): TFAM |
| [66] | Muscle | Humans | Youths, middle-aged, and elderly | NS: OPA1; Mfn2; Fis1; Drp1; Bnip3; beclin1; LC3II/I |
| [60] | Muscle | Mouse | Youths/elderly | ↑: Mfn2/Drp1 |
| NS: OPA; Drp1; Mfn1; Mfn2 |
| [44] | Muscle | Rats | Youths/elderly | NS: Drp1; beclin1; LC3II |
| ↑: Parkin; Fis1; OPA1; Mfn2 |
| [56] | Brain | Rats | Youths/elderly | ↑: TFAM |
| [52] | Liver | Rats | Middle-aged, old (18 m), and very old (28 m) | ↓: TFAM; PGC-1α |
| NS: VDAC |
| [57] | Brain, muscle, and liver | Rats | Middle-aged, old (18 m), and very old (28 m) | ↑ (brain): TFAM |
| ↓ (muscle and liver): TFAM |
| [64] | Muscle | Mouse | Youths/elderly | ↑: Bnip3; LC3II; LC3II/I |
| ↓: Mfn2 |
| NS: LC3I |
| [61] | Brain | Mouse | Youth, middle-aged, and elderly | ↓: TFAM; Drp1; Mfn2 |
| ↑: OPA1; Mfn1 |
| [53] | Heart | Humans | Youths/elderly | ↓: PGC-1α |
| [75] | Muscle | Humans | Youths/elderly | ↓: LC3II/I |
| NS: beclin1 |
| [10] | PBMCs | Humans | Youths/elderly | ↓: LC3II/I; beclin1 |
|
