Apigenin Alleviates Endotoxin-Induced Myocardial Toxicity by Modulating Inflammation, Oxidative Stress, and Autophagy

Figure 6

Apigenin attenuates LPS-induced cardiac NFκB nuclear translocation and oxidative damage. (a) Western blot analyses of NFκB (p65) in nuclear and cytoplasmic fractions from heart lysates. Histone H3 was used as a nuclear control whereas tubulin was used as a cytoplasmic control. (b) Cardiac oxidative markers protein nitration and carbonyl content measured by quantitative ELISA. All markers were significantly increased in LPS-treated mice. Apigenin significantly reduced LPS-induced oxidative stress markers. Values represented as means ± SD; and .

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