Apigenin Alleviates Endotoxin-Induced Myocardial Toxicity by Modulating Inflammation, Oxidative Stress, and Autophagy

<div>Apigenin enhances LPS-induced TFEB nuclear localization and its downstream genes Vps11 and Map1lc3. (a) Western blot analyses of TFEB in nuclear and cytoplasmic fraction from heart lysates. Histone H3 was used as a nuclear control whereas tubulin was used as a cytoplasmic control. (b) TFEB-regulated genes Map1lc3 and Vps11 were examined at mRNA level by real-time PCR. LPS induced mRNA level in both genes whereas apigenin further enhanced those mRNA expression. 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Oxidative Medicine and Cellular Longevity

fig9

Figure 9

Figure 9: Apigenin Alleviates Endotoxin-Induced Myocardial Toxicity by Modulating Inflammation, Oxidative Stress, and Autophagy 