Nrf2, a Potential Therapeutic Target against Oxidative Stress in Corneal Diseases

Figure 2

Schematic diagram of Nrf2 signaling and regulation in the corneal endothelial cells. TBHP and H₂O₂, both high and low fluences of UVA, can induce excessive ROS generation in corneal endothelial cells, leading to apoptosis and cell death. SFN can inhibit tBHP-induced ROS generation, apoptosis, and cell death. Meantime, it can increase DJ-1 protein expression and Nrf2 translocation and induce Nrf2/ARE-dependent antioxidant enzyme (HO-1 and NQO1) transcriptions.