Increased Oxidative Damage of RNA in Early-Stage Nephropathy in db/db Mice

Table 1

Biochemical and physical characteristics of experimental groups.

Characteristic	db/m—4 w	db/db—4 w	db/m—8 w	db/db—8 w	db/m—12 w	db/db—12 w	db/m—16 w	db/db—16 w
Body weight (g)	15.5 ± 1.4	23.8 ± 0.8	23.8 ± 1.4	45.7 ± 2.1	26.7 ± 1.3	48.9 ± 5.0	28.9 ± 2.6	44.5 ± 3.5
Kidney weight (mg)	142.3 ± 8.8	173.6 ± 29.7	176.2 ± 17.9	238.7 ± 67.6	174.3 ± 13.4	234 ± 26.4	186.8 ± 25.7	222.7 ± 40.6
Kidney wt/body wt, ×10^−3	8.0 ± 0.5	5.3 ± 1.0	7.8 ± 0.7	5.2 ± 1.3	7.5 ± 0.5	4.9 ± 0.6	7.6 ± 0.8	5.5 ± 1.1
Blood glucose (mmol/L)	7.9 ± 0.5	13.4 ± 3.9	8.1 ± 0.8	24.1 ± 5.5	6.8 ± 0.6	29.7 ± 2.9	6.8 ± 0.3	34.7 ± 3.2
Plasma creatinine (mg/dL)	0.094 ± 0.007	0.083 ± 0.01	0.088 ± 0.01	0.089 ± 0.01	0.093 ± 0.005	0.103 ± 0.02	0.096 ± 0.008	0.106 ± 0.01