2-Deoxy-D-glucose Restore Glucocorticoid Sensitivity in Acute Lymphoblastic Leukemia via Modification of N-Linked Glycosylation in an Oxygen Tension-Independent Manner

Figure 8

High-throughput screen of protein kinase inhibitors in SD1 and REH leukemia cells. (a) Heat map of REH representing the top candidates from the drug screen upon single and cotreatment with MP. SB-360741, a powerful GSK-3 inhibitor, is indicated by a red arrow. The values shown were calculated as a percentage of the DMSO-treated control. Protein expression profiles of leukemia cell lines, SD1 and REH, upon single or combinatorial treatment with (b) MP and SB-360741or (c) MP and 2-DG.

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