Effect of Multicomponent Training on Blood Pressure, Nitric Oxide, Redox Status, and Physical Fitness in Older Adult Women: Influence of Endothelial Nitric Oxide Synthase (NOS3) Haplotypes
Table 6
Effects of 12 weeks of multicomponent training on oxidative stress and antioxidant activity of 52 older adult women grouped by haplotype (H1–H8).
Haplotypes
MDA (μM) before
MDA (μM) after
∆%
GSH (μM) before
GSH (μM) after
∆%
TAC (μM) before
TAC (μM) after
∆%
-786T>C
Intron 4
Glu298 Asp
H1
T
4b
Glu
4.8 (1.5)a
2.5 (0.8)
−78.8
3.6 (0.5)
3.9 (1)
8.3
0.33 (0.10)
0.40 (0.12)∗
21.2
H2
T
4b
Asp
4 (1.2)a
1.9 (0.5)
−53.4
3.7 (0.4)
3.8 (0.8)
1.3
0.30 (0.05)
0.35 (0.02)
16.7
H3
T
4a
Glu
7.3 (3.2)
5.5 (2.7)
−24.4
3.6 (0.7)
3.6 (0.7)
0
0.33 (0.19)
0.36 (0.15)
9.1
H4
T
4a
Asp
—
—
—
—
—
—
—
—
—
H5
C
4b
Glu
—
—
—
—
—
—
—
—
—
H6
C
4b
Asp
5.3 (1.6)a
2.5 (0.8)
−52.7
3.6 (0.8)
3.7 (0.9)
1.9
0.33 (0.09)
0.42 (0.15)
27.3
H7
C
4a
Glu
4.5 (1.1)a
2.7 (1.1)
−40.7
3.4 (0.4)
3.4 (0.6)
−0.3
0.37 (0.14)
0.41 (0.11)
10.8
H8
C
4a
Asp
4.3 (1.2)a
2.2 (0.3)
−47.4
3.2 (0.4)
3 (0.2)
−8.1
0.29 (0.10)
0.35 (0.08)
20.7
Data are reported as means (SD) before and after 12 weeks of multicomponent training for 52 women. MDA = malondialdehyde; GSH = glutathione; TAC = total antioxidant capacity. compared with before intervention (the same group). a versus H3 before intervention. Linear mixed-effects models.
