Review Article

Antiobesity Effects of Anthocyanins in Preclinical and Clinical Studies

Table 1

Clinical studies retrieved from the http://ClinicalTrials.gov database on anthocyanins and obesity.

Trial number statusConditions and dosageObjectivesPrimary outcomeNumber of subjects (age/sex)

NCT02613715 (completed)Overweight and obesity (250 ml of blackberry juice)To evaluate the bioavailability of blackberry juice anthocyanins in normal weight and overweight/obese adultsPlasma concentrations of anthocyanins and anthocyanin metabolites18 (18–40/M-F)
NCT01180712 (recruiting)Type 2 diabetes (1.4 g of concentrated blackberry extract mirtoselect provided by Indena S.p.A.)To determine the effects of anthocyanin supplementation in the form of a concentrated blackberry extract on insulin resistance and inflammation particularly in the adipose tissueOral glucose tolerance test60 (40–70/M)
NCT01883401 (completed)Dyslipidemia; obesity (25–50 g freeze-dried strawberries/day)To determine the effects of low and high doses of freeze-dried strawberries in cardiovascular risk factors in subjects with abdominal adiposity and dyslipidemiaChange in lipids and lipoproteins60 (19–72/M-F)
NCT01005420 (completed)Insulin sensitivity (45 g of blueberry powder)To evaluate the effect of blueberry powder on insulin sensitivity in obese, nondiabetic, and insulin-resistant subjects.Insulin sensitivity37 (>20/M-F)
NCT02689765 (completed)Insulin resistance; glucose and lipid metabolism disorders; type 2 diabetes (80 g of a mixture of fresh blueberries and blackcurrants)To characterize the potential effects of anthocyanins, purified from bilberries and blackcurrants, on metabolic zabnormalities commonly associated with type 2 prediabetesChange in fasting glucose and HbA1C160 (40–75/M-F)
NCT01705093 (unknown)Childhood obesity; cardiovascular disease (50 g of flavonoid-rich freeze-dried strawberry powder)To verify if strawberry intake can lead to improvements in select measures of cardiovascular function in overweight and obese adolescent malesVascular function measured by peripheral arterial tonometry25 (14–18/M)
NCT02035592 (active, but not recruiting)Insulin resistance; metabolic syndrome X (13–26 g of freeze-dried blueberry powder per day)To determine the dose-dependent impact of blueberry powder intake on insulin sensitivity and resistance, cardiovascular disease risk factors, and lung and cognitive function in overweight and obese participants with metabolic syndromeInsulin resistance144 (50–74/M-F)
NCT02291250 (recruiting)Type 2 diabetes (200 g of blackcurrants, which contain anthocyanins, or 200 g greencurrants, which naturally contain no anthocyanins)To investigate the acute effect blackcurrants on glucose metabolism in overweight/obese volunteersPlasma glucose area under the curve16 (21–70/M-F)
NCT02800967 (active, but not recruiting)Hypertension; overweight (pure Aronia juice with appx. polyphenol content of 1000 mg gallic acid equivalents/100 ml)To investigate the effects of Aronia juice polyphenols on platelet function and other CVD risk factors in subjects with moderate CVD riskChanges in the percentage of P-selectin and glycoprotein IIbIIIa (GPIIbIIIa) positive platelets, percentage of platelet-monocyte, and platelet-neutrophil aggregates84 (30–50/M-F)
NCT01564498 (recruiting)Hypertension; hypercholesterolemia; type II diabetes; obesity; inflammation (300–500 g of cooked white/purple potatoes per day, or 300–500 g of raw orange/purple carrots per day)To verify if purple vegetables, rich in polyphenolic compounds including anthocyanins, can have higher antioxidant and other biological activities than more lightly coloured versions of these foodsBlood cholesterol60 (18–65/M-F)