Oxidative Medicine and Cellular Longevity / 2017 / Article / Tab 1

Clinical Study

Effect of Vitamin D Receptor Activation on the AGE/RAGE System and Myeloperoxidase in Chronic Kidney Disease Patients

Table 1

Demographic, clinical, and biochemical characteristics of the two study arms at baseline.

Active group ()Placebo group ()

Age (years)63 ± 1162 ± 120.65
Male sex (%)59%70%0.27
Current smokers (%)12%19%0.37
Past smokers (%)45%41%0.66
Diabetes (%)34%36%0.82
BMI (kg/m2)29 ± 529 ± 50.66
Systolic/diastolic BP (mmHg)123 ± 16/73 ± 9129 ± 21/73 ± 110.16/0.81
Heart rate (beats/min)67 ± 868 ± 100.64
Cholesterol (mg/dL)164 ± 41162 ± 430.84
HDL cholesterol (mg/dL)47 ± 1150 ± 130.18
LDL cholesterol (mg/dL)88 ± 3488 ± 360.91
eGFRCyst (mL/min/1.73m2)34 ± 1229 ± 130.06
Hemoglobin (g/dL)12 ± 212 ± 20.49
Calcium (mmol/L)2.25 ± 0.122.21 ± 0.100.16
Phosphate (mmol/L)1.20 ± 0.191.23 ± 0.160.29
Parathormone (pg/mL)102 (81–146)102 (85–154)0.70
FGF-23 (pg/mL)64.7 (52.7–81.2)78.0 (53.7–103.1)0.07
1,25-OH vitamin D (pmol/L)101.4 ± 41.693.6 ± 41.80.32
25-OH vitamin D (nmol/L)33 ± 1638 ± 160.19
C-reactive protein (mg/L)1.18 (0.68–3.02)2.49 (0.99–3.74)0.11
S100A12/ENRAGE (ng/mL)165 (103–469)175 (88–272)0.39
Pentosidine (pmol/mL)43.6 (31.2–108.9)44.1 (31.2–99.5)0.87
Human RAGE (pg/mL)2072 (1571–2984)2027 (1481–2794)0.81
Myeloperoxidase (ng/mL)128.5 (71.5–204.0)127.8 (91.5–176.8)0.90

Data are expressed as mean ± SD, median and interquartile range, or percent frequency as appropriate. BMI: body mass index; BP: blood pressure; LDL: low-density lipoprotein; HDL: high-density lipoprotein; eGFR: estimated glomerular filtration rate; FGF-23: fibroblast growth factor-23.

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